Serum Biomarkers Workshop Available to Watch on ICE-HBV YouTube Page.

POSTED ON: 22 Oct, 2020

ICE-HBV would like to thank all chairs, presenters, panellists and attendees for the great experience of the 2020 Serum Biomarkers Workshop that was held on the 5th and 12th of October via Zoom.

Videos from all presentations and panel discussions are now available on the new ICE-HBV YouTube page.

Links to the abstracts, slides and videos of all presentations are also available on our Serum Biomarkers Workshop page here.

Thanks again to all who presented and attended for making it a very smoothly running and informative workshop.

A Community Update on the Progress to a Hepatitis B Cure: Webinar

POSTED ON: 09 Oct, 2020

“A Community Update on the Progress to a Hepatitis B Cure” was a Webinar hosted by the Hepatitis B Foundation and ICE-HBV. Presentation video and slides are available below.

The next webinar is on the 20th of October from 3-4pm Eastern Time to discuss the connection between Hepatitis B and Liver Cancer and strategies for preventing liver cancer for those with hepatitis B.

See a recording of the Presentation.

See Presentation slides.

Updates from ILC 2020: The pipeline for hepatitis B and D treatment

POSTED ON: 31 Aug, 2020

Abstract from ILC 2020 Newsletter:

Although there are highly effective therapies for hepatitis B infection, none currently offer the reliable prospect of a cure and there are few available options for hepatitis D. Today, progress towards the development of curative treatments for hepatitis B and HBV/HDV coinfection were showcased at Digital ILC 2020, with novel molecules encompassing several mechanisms of action.

Results from trials of three agents targeting the transcription of viral proteins were reported: the RNA interference (RNAi) therapy VIR-2218 and the antisense oligonucleotides ISIS 505358/GSK3228836 and RO7062931. All showed reductions in hepatitis B surface antigen, particularly in patients also receiving nucleos(t)ide reverse transcriptase inhibitors.
Phase 2 clinical trials in virally suppressed chronic hepatitis B patients have also demonstrated initial efficacy and favourable safety profiles for the hepatitis B core inhibitor ABI-H0731 and the oral TLR8 agonist, selgantolimod. These two therapies work through direct targeting of viral proteins and immunomodulation, respectively, showing the potential viability of multiple routes towards a cure for hepatitis B.

In patients with chronic HBV/HDV coinfection, high-doses of first-in-class entry inhibitor bulevirtide, administered in combination with PEG-IFNα or tenofovir, were well tolerated and led to continuous decline in HDV RNA that was maintained over 48 weeks of treatment. This highlights a potential new treatment option for the most severe form of viral hepatitis and a significant unmet need in the field.

Find out more on https://easl.eu/

HBV Serum Biomarkers Workshop Programme Released

POSTED ON: 21 Aug, 2020

ICE-HBV is organizing an virtual and interactive workshop on HBV biomarkers endorsed by the International HBV Meeting. The event is aimed at scientists, clinicians, pharmaceutical and diagnostic industry representatives.  The workshop, chaired by Anna Kramvis and Peter Revill, is put together by the ICE-HBV serum biomarkers working group. Both classic and future biomarkers will be discussed. The workshop will lead to a consensus statement on promising serum biomarkers. 

The programme and registration system can be found here: https://ice-hbv.org/hbv-serum-biomarkers-workshop/