Find Pr Zoulim’s insight on HBV elimination and the importance of HBV cure research on this video from Dr Helene Drouin & learn more a bout her project to reach the top of Everest to support HBV cure research.
ICE-HBV would like to thank all chairs, presenters, panellists and attendees for the great experience of the 2020 Serum Biomarkers Workshop that was held on the 5th and 12th of October via Zoom.
Videos from all presentations and panel discussions are now available on the new ICE-HBV YouTube page.
Links to the abstracts, slides and videos of all presentations are also available on our Serum Biomarkers Workshop page here.
Thanks again to all who presented and attended for making it a very smoothly running and informative workshop.
“A Community Update on the Progress to a Hepatitis B Cure” was a Webinar hosted by the Hepatitis B Foundation and ICE-HBV. Presentation video and slides are available below.
The next webinar is on the 20th of October from 3-4pm Eastern Time to discuss the connection between Hepatitis B and Liver Cancer and strategies for preventing liver cancer for those with hepatitis B.
At the 2020 COLDA conference on Friday the 11th of September, Dr Massimo Levrero presented HBV Cure Science 101 on behalf of ICE-HBV.
Abstract from ILC 2020 Newsletter:
Although there are highly effective therapies for hepatitis B infection, none currently offer the reliable prospect of a cure and there are few available options for hepatitis D. Today, progress towards the development of curative treatments for hepatitis B and HBV/HDV coinfection were showcased at Digital ILC 2020, with novel molecules encompassing several mechanisms of action.
Results from trials of three agents targeting the transcription of viral proteins were reported: the RNA interference (RNAi) therapy VIR-2218 and the antisense oligonucleotides ISIS 505358/GSK3228836 and RO7062931. All showed reductions in hepatitis B surface antigen, particularly in patients also receiving nucleos(t)ide reverse transcriptase inhibitors.
Phase 2 clinical trials in virally suppressed chronic hepatitis B patients have also demonstrated initial efficacy and favourable safety profiles for the hepatitis B core inhibitor ABI-H0731 and the oral TLR8 agonist, selgantolimod. These two therapies work through direct targeting of viral proteins and immunomodulation, respectively, showing the potential viability of multiple routes towards a cure for hepatitis B.
In patients with chronic HBV/HDV coinfection, high-doses of first-in-class entry inhibitor bulevirtide, administered in combination with PEG-IFNα or tenofovir, were well tolerated and led to continuous decline in HDV RNA that was maintained over 48 weeks of treatment. This highlights a potential new treatment option for the most severe form of viral hepatitis and a significant unmet need in the field.
Find out more on https://easl.eu/
ICE-HBV is organizing an virtual and interactive workshop on HBV biomarkers endorsed by the International HBV Meeting. The event is aimed at scientists, clinicians, pharmaceutical and diagnostic industry representatives. The workshop, chaired by Anna Kramvis and Peter Revill, is put together by the ICE-HBV serum biomarkers working group. Both classic and future biomarkers will be discussed. The workshop will lead to a consensus statement on promising serum biomarkers.
The programme and registration system can be found here: https://ice-hbv.org/hbv-serum-biomarkers-workshop/
“The global burden of viral hepatitis is substantial; in terms of mortality, hepatitis B virus and hepatitis C virus infections are on a par with HIV, malaria and tuberculosis, among the top four global infectious diseases. In 2016, the 194 Member States of the World Health Organization committed to eliminating viral hepatitis as a public health threat by 2030, with a particular focus on hepatitis B virus and hepatitis C virus infection. With only 10 years to go until the 2030 deadline is reached, and although much progress has been made towards elimination, there are still some important gaps in terms of policy and progress. In this Viewpoint, we asked a selection of scientists and clinicians working in the viral hepatitis field for their opinions on whether elimination of viral hepatitis by 2030 is feasible, what the key areas of progress are and what the focus for the next 10 years and beyond should be for viral hepatitis elimination.”
Find this #WorldHepatitisDay opinion piece from ICE-HBV incoming chair Fabien Zoulim and colleagues here.
ICE-HBV is celebrating World Hepatitis Day 2020 with this video on hepatitis B, please share to your networks.
ICE-HBV and Brown Dog Productions created this video in collaboration with the Doherty Institute, the Hepatitis B Foundation and the World Hepatitis Alliance, with support from its sponsors.
Despite the existence of an excellent preventative vaccine and antiviral therapies which effectively control the virus, chronic hepatitis B affects 257 million people and is one of the leading causes of death worldwide. The global hepatitis B research community is working together with people living with hepatitis B to develop cures and many approaches are currently in early stage clinical trials. Until these cures are available, it is imperative that people are tested and receive the life-saving antiviral treatment to control their HBV infection and prevent liver disease.
ICE-HBV encourages more people to get tested and treated for chronic HBV, and to let people living with HBV know that the global HBV research community is in their corner and is striving for a cure, so we can live a #hepfreefuture
ICE-HBV, The Hepatitis B Foundation and the World Hepatitis Alliance came together with many other stakeholders and agreed on the shortest route to HBV elimination. Check out their briefing here and use this in your activities with policy makers and lay audiences.