ICE-HBV 2018-2022 Key Goals

Fluorescently conjugated antigen-bait systems have been extensively used to identify antigen-specific B cells and probe humoral immunity across dif... [Read more]

The frequency of HBV-specific CD8+ T cells can be very low, depending on the specificity. Therefore, they cannot always be detected by conventional... [Read more]

• Although a plethora of knowledge on the molecular life cycle of Hepatitis B Virus has been gained by utilizing classical methods, they ... [Read more]

• This assay characterizes the products of HBV RNase H activity on a DNA:RNA heteroduplex.
• Products are resolved by denaturin... [Read more]

• This assay detects the activity of HBV RNaseH using fluorescence resonance energy transfer
• The ribonuclease H (RNaseH) subs... [Read more]

• As an essential component of HBV life cycle, the viral covalently closed circular DNA (cccDNA) is synthesized and maintained at low cop... [Read more]

• Besides human, only a few species have been reported to be permissive for Hepatitis B virus (HBV) infection(1-3). Human liver chimeric ... [Read more]

• HBV polymerase activity is assayed by measuring its ability to bind viral RNA at a secondary-structure motif, the epsilon (e) stem-loop... [Read more]

• HBV polymerase activity is assayed by measuring the first step in DNA synthesis, protein priming, wherein the polymerase becomes nucleo... [Read more]

• This protocol describes the infection of liver humanized mice (here UPA/SCID mice) with hepatitis B and /or hepatitis D viruses.
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