ICE-HBV Structure

The frequency of HBV-specific CD8+ T cells can be very low, depending on the specificity. Therefore, they cannot always be detected by conventional [Read more]

• Although a plethora of knowledge on the molecular life cycle of Hepatitis B Virus has been gained by utilizing classical methods, they can... [Read more]

• This assay characterizes the products of HBV RNase H activity on a DNA:RNA heteroduplex.
• Products are resolved by denaturing P... [Read more]

• This assay detects the activity of HBV RNaseH using fluorescence resonance energy transfer
• The ribonuclease H (RNaseH) substra... [Read more]

• As an essential component of HBV life cycle, the viral covalently closed circular DNA (cccDNA) is synthesized and maintained at low copy n... [Read more]

• Besides human, only a few species have been reported to be permissive for Hepatitis B virus (HBV) infection(1-3). Human liver chimeric mou... [Read more]

• HBV polymerase activity is assayed by measuring its ability to bind viral RNA at a secondary-structure motif, the epsilon (e) stem-loop st... [Read more]

• HBV polymerase activity is assayed by measuring the first step in DNA synthesis, protein priming, wherein the polymerase becomes nucleotid... [Read more]

• This protocol describes the infection of liver humanized mice (here UPA/SCID mice) with hepatitis B and /or hepatitis D viruses.
• W... [Read more]

• Immunocompetent mouse models that allow for the investigation of virus replication and the immune response to HBV include hydrodynamic injec... [Read more]