Hot topics on HBV & HDV Clinical trials, immune exhaustion & immune clearance, cccDNAbiology and targeting, viral integration, viral biomarkers, experimental study models.

This workshop is endorsed by ICE-HBV.

ICE-HBV & EASL will present their joint HBV Cure Think Tank once again in 2020! Find out more here.

ICE-HBV and its members will have a strong presence at HepDART 2019, with many important presentations on HBV Cure such as:

Clinical update on drugs for HBV cure* 
Harry Janssen, University of Toronto, Canada

What would an HBV cure look? Endpoints and clinical trial design towards a cure* 
Anna Lok, University of Michigan, USA

Join them in Hawai by registering here.

ICE-HBV & partners are organizing a session at the Global Fund’s replenishment conference in Lyon. Please contact info@ice-hbv.org to register (free).

The goal of this session is to underscore the potential public health impact of expanding viral hepatitis elimination programming, including through strategic integration with existing efforts to improve HIV care and prevention outcomes. The full programme is available here.

 

ICE-HBV is organizing an HBV Cure 101 session at COLDA to enhance awareness about HBV Cure research in Africa. Anna Kramvis will represent ICE-HBV and share an update about the latest sience before discussing cure prospects with Manal El-Sayed (Clinician) and Kenneth Kabagambe (Community).

More here.

 

The 6th edition of the International HBV Cure Workshop 2019, which will take place on 6 November 2019 in Toronto, Canada. Since 2014, the HBV Cure Workshop is a scientific platform that acts as a catalyst to accelerate the progress for achieving a cure. This meeting will bring together the world’s leading basic, translational and clinical experts to share and discuss the latest research outcomes and challenges.

 

Details can be found here.

ICE-HBV in-vivo models project group is holding a workshop immediately before the International HBV Meeting. If you wish to attend, you can register here.

The objectives are:
1. Evaluation of current available models and their respective usage in various basic studies and drug assessment. Each presenter to perform a SWAT/comparative analysis of the models they present.

2. Discussion on features needed for an ideal model for assessing agent(s) with curative potential

3. Gap analysis and roadmap for developing models amenable for HBV infection and disease development. The roadmap will be published as review article/opinion piece.

The full programme can be found below and printed here.

ICE-HBV welcome and introductions	T. Jake Liang	8:30-8:40
What we learned about HBV pathogenesis and immune intervention in chimpanzees, woodchucks and immunocompetent transgenic mice	Luca G. Guidotti	8-40-9:15
Comparison of the Adeno-HBV, the AAV-HBV and the HBVtg mouse models	Ulla Protzer	9:15-9:50
Break
Hydrodynamic injection mouse model	Pei-Jer Chen	10:05-10:25
Mouse models based on stem cell derived hepatocytes/FAH	Alexander Ploss	10:25-10:45
Human liver chimeric mice and their application for drug assessment	Maura Dandri	10:45-11:20
Liver and immune system humanized mouse models to study pathophysiology and therapeutics.	Hélène Strick Marchand	11:20 – 11:55
Lunch Break
Mouse with humanized NTCP	Wenhui Li	13:00-13:20
Towards a mouse model susceptible to HBV infection – overcoming the barrier to cccDNA formation.	Jianming Hu	13:20-13:35
Macaque with human NTCP for HBV infection	Ben Burwitz	13:35-13:55
Industry perspective in most wanted features for HBV animal models	Scott Balsitis	13:55-14:30
Panel Discussion (facilitation by T. Jake Liang)	All speakers	14:30-15:10
Closing	Hélène Strick Marchand & Wenhui Li	15h10-15h30

In 2019, the IAS Towards an HIV Cure initiative, in collaboration with the International Coalition to Eliminate Hepatitis B (ICE-HBV), will organize a 1.5 day HIV & HBV Cure Forum on 20 & 21 July 2019, immediately preceding the 10th IAS Conference on HIV Science (IAS 2019).

Abstract are accepted until 22 January 2019. Use the IAS 2019 system to submit.

Learn more about the Forum here.

The International HBV Meeting is coming to Melbourne, the home-base of ICE-HBV. We will take this opportunity to co-organize a public forum, stay tuned! http://www.hbvmeeting.org/