Tue01Oct20198:30 amMelbourne Convention Centre
Melbourne in-vivo models workshop
The objectives are:
1. Evaluation of current available models and their respective usage in various basic studies and drug assessment. Each presenter to perform a SWAT/comparative analysis of the models they present.
2. Discussion on features needed for an ideal model for assessing agent(s) with curative potential
3. Gap analysis and roadmap for developing models amenable for HBV infection and disease development. The roadmap will be published as review article/opinion piece.
The full programme can be found below and printed here.
ICE-HBV welcome and introductions T. Jake Liang 8:30-8:40 What we learned about HBV pathogenesis and immune intervention in chimpanzees, woodchucks and immunocompetent transgenic mice Luca G. Guidotti 8-40-9:15 Comparison of the Adeno-HBV, the AAV-HBV and the HBVtg mouse models Ulla Protzer 9:15-9:50 Break Hydrodynamic injection mouse model Pei-Jer Chen 10:05-10:25 Mouse models based on stem cell derived hepatocytes/FAH Alexander Ploss 10:25-10:45 Human liver chimeric mice and their application for drug assessment Maura Dandri 10:45-11:20 Liver and immune system humanized mouse models to study pathophysiology and therapeutics. Hélène Strick Marchand 11:20 – 11:55 Lunch Break Mouse with humanized NTCP Wenhui Li 13:00-13:20 Towards a mouse model susceptible to HBV infection - overcoming the barrier to cccDNA formation. Jianming Hu 13:20-13:35 Macaque with human NTCP for HBV infection Ben Burwitz 13:35-13:55 Industry perspective in most wanted features for HBV animal models Scott Balsitis 13:55-14:30 Panel Discussion (facilitation by T. Jake Liang) All speakers 14:30-15:10 Closing Hélène Strick Marchand & Wenhui Li 15h10-15h30